TOMM20

TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases associated with TOMM20 include Perry Syndrome and Neurodegeneration With Brain Iron Accumulation 2A. Among its related pathways are Pink/Parkin Mediated Mitophagy and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.

TOMM20 Gene(Protein Coding) Translocase Of Outer Mitochondrial Membrane 20

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.

Biological Process protein import into mitochondrial matrix Source:GO_Central1 Publication
Biological Process protein insertion into mitochondrial outer membrane Source:ComplexPortal1 Publication
Biological Process protein targeting to mitochondrion Source:HGNC-UCL1 Publication
Biological Process tRNA import into mitochondrion Source:GO_Central1 Publication

Mitochondrion outer membrane

Mitochondrial intermembrane: 1-6
Helical: 7-24
Cytoplasmic: 25-145

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.