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TOMM20

TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases associated with TOMM20 include Perry Syndrome and Neurodegeneration With Brain Iron Accumulation 2A. Among its related pathways are Pink/Parkin Mediated Mitophagy and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.
Full Name
TOMM20 Gene(Protein Coding) Translocase Of Outer Mitochondrial Membrane 20
Function
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
Biological Process
Biological Process protein import into mitochondrial matrix Source:GO_Central1 Publication
Biological Process protein insertion into mitochondrial outer membrane Source:ComplexPortal1 Publication
Biological Process protein targeting to mitochondrion Source:HGNC-UCL1 Publication
Biological Process tRNA import into mitochondrion Source:GO_Central1 Publication
Cellular Location
Mitochondrion outer membrane
Topology
Mitochondrial intermembrane: 1-6
Helical: 7-24
Cytoplasmic: 25-145
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
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Anti-TOMM20 antibodies

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Rabbit Anti-TOMM20 Recombinant Antibody (D8T4N) (CBMAB-CP2822-LY)

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Target: TOMM20
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D8T4N
Application*: WB, IP, P, IF (IC)
Datasheet SDS

Mouse Anti-TOMM20 Recombinant Antibody (CBYJT-4171) (CBMAB-T3624-YJ)

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Target: TOMM20
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat
Clone: CBYJT-4171
Application*: WB, IF
Datasheet SDS

Rabbit Anti-TOMM20 Recombinant Antibody (CBYJT-4169) (CBMAB-T3622-YJ)

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Target: TOMM20
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-4169
Application*: WB, P, F, IC, IF
Datasheet SDS

Mouse Anti-TOMM20 Recombinant Antibody (CBYJT-4168) (CBMAB-T3621-YJ)

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Target: TOMM20
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-4168
Application*: E, IF, P, WB
Datasheet SDS

Rabbit Anti-TOMM20 Recombinant Antibody (CBYJT-4167) (CBMAB-T3620-YJ)

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Target: TOMM20
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-4167
Application*: WB, P, IF, IC, IP, F
Datasheet SDS

Mouse Anti-TOMM20 Recombinant Antibody (CBYJT-4166) (CBMAB-T3619-YJ)

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Target: TOMM20
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-4166
Application*: E, IF, IH, WB
Datasheet SDS

Rabbit Anti-TOMM20 Recombinant Antibody (CBYJT-4165) (CBMAB-T3618-YJ)

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Target: TOMM20
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: CBYJT-4165
Application*: IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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