Mouse Anti-TOMM20 Recombinant Antibody (CBYJT-4168) (CBMAB-T3621-YJ)

Name: Mouse Anti-TOMM20 Recombinant Antibody (CBYJT-4168)
SKU: CBMAB-T3621-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4168

Application

ELISA, IF, IHC-P, WB

Immunogen

TOMM20 (AAH66335, 1 a.a. ~ 146 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-146

More Infomation

Target

Full Name

TOMM20 Gene(Protein Coding) Translocase Of Outer Mitochondrial Membrane 20

Introduction

TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases related to TOMM20 include Perry Syndrome and Neurodegeneration With Brain Iron Accumulation 2A. Among its related pathways are Pink/Parkin Mediated Mitophagy and Metabolism of proteins. Gene Ontology (GO) annotations related to TOMM20 include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of TOMM20 is TOMM20L.

Entrez Gene ID

Human	9804
Mouse	67952
Rat	266601

UniProt ID

Human	Q15388
Mouse	Q9DCC8
Rat	Q62760

Alternative Names

Translocase Of Outer Mitochondrial Membrane 20; Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II; Mitochondrial 20 KDa Outer Membrane Protein; Outer Mitochondrial Membrane Receptor Tom20; Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast); Mitochondrial Import Receptor Subunit TOM20 Homolog

Function

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.

Biological Process

Biological Process protein import into mitochondrial matrix Source:GO_Central1 Publication
Biological Process protein insertion into mitochondrial outer membrane Source:ComplexPortal1 Publication
Biological Process protein targeting to mitochondrion Source:HGNC-UCL1 Publication
Biological Process tRNA import into mitochondrion Source:GO_Central1 Publication

Cellular Location

Mitochondrion outer membrane

Topology

Mitochondrial intermembrane: 1-6
Helical: 7-24
Cytoplasmic: 25-145

PTM

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Rabbit Anti-TOMM20 Recombinant Antibody (CBYJT-4165) (CAT#: CBMAB-T3618-YJ)

Mouse Anti-TOMM20 Recombinant Antibody (CBYJT-4166) (CAT#: CBMAB-T3619-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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