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Mouse Anti-TOMM20 Recombinant Antibody (CBYJT-4168) (CBMAB-T3621-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TOMM20 (Translocase Of Outer Mitochondrial Membrane 20). The antibody can be used for immunoassay techniques, such as ELISA, IF, IHC-P, WB.
See all TOMM20 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-4168
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
TOMM20 (AAH66335, 1 a.a. ~ 146 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-146

Target

Full Name
TOMM20 Gene(Protein Coding) Translocase Of Outer Mitochondrial Membrane 20
Introduction
TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases related to TOMM20 include Perry Syndrome and Neurodegeneration With Brain Iron Accumulation 2A. Among its related pathways are Pink/Parkin Mediated Mitophagy and Metabolism of proteins. Gene Ontology (GO) annotations related to TOMM20 include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of TOMM20 is TOMM20L.
Entrez Gene ID
Human9804
Mouse67952
Rat266601
UniProt ID
HumanQ15388
MouseQ9DCC8
RatQ62760
Alternative Names
Translocase Of Outer Mitochondrial Membrane 20; Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II; Mitochondrial 20 KDa Outer Membrane Protein; Outer Mitochondrial Membrane Receptor Tom20; Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast); Mitochondrial Import Receptor Subunit TOM20 Homolog
Function
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
Biological Process
Biological Process protein import into mitochondrial matrix Source:GO_Central1 Publication
Biological Process protein insertion into mitochondrial outer membrane Source:ComplexPortal1 Publication
Biological Process protein targeting to mitochondrion Source:HGNC-UCL1 Publication
Biological Process tRNA import into mitochondrion Source:GO_Central1 Publication
Cellular Location
Mitochondrion outer membrane
Topology
Mitochondrial intermembrane: 1-6
Helical: 7-24
Cytoplasmic: 25-145
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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