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Rabbit Anti-TOMM20 Recombinant Antibody (D8T4N) (CBMAB-CP2822-LY)

The product is antibody recognizes TOMM20. The antibody D8T4N immunoassay techniques such as: WB,IP,IHC-P,IF (ICC).
See all TOMM20 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D8T4N
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Tom20 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TOMM20 Gene(Protein Coding) Translocase Of Outer Mitochondrial Membrane 20
Introduction
TOMM20 (Translocase Of Outer Mitochondrial Membrane 20) is a Protein Coding gene. Diseases associated with TOMM20 include Perry Syndrome and Neurodegeneration With Brain Iron Accumulation 2A. Among its related pathways are Pink/Parkin Mediated Mitophagy and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include unfolded protein binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity. An important paralog of this gene is TOMM20L.
Entrez Gene ID
Human9804
Mouse67952
Rat266601
Monkey712039
UniProt ID
HumanQ15388
MouseQ9DCC8
RatQ62760
MonkeyF7DT16
Alternative Names
Translocase Of Outer Mitochondrial Membrane 20; Translocase Of Outer Mitochondrial Membrane 20 Homolog Type II; Mitochondrial 20 KDa Outer Membrane Protein; Outer Mitochondrial Membrane Receptor Tom20; Translocase Of Outer Mitochondrial Membrane 20 Homolog (Yeast); Mitochondrial Import Receptor Subunit TOM20 Homolog;
Function
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).
Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
Biological Process
Biological Process protein import into mitochondrial matrix Source:GO_Central1 Publication
Biological Process protein insertion into mitochondrial outer membrane Source:ComplexPortal1 Publication
Biological Process protein targeting to mitochondrion Source:HGNC-UCL1 Publication
Biological Process tRNA import into mitochondrion Source:GO_Central1 Publication
Cellular Location
Mitochondrion outer membrane
Topology
Mitochondrial intermembrane: 1-6
Helical: 7-24
Cytoplasmic: 25-145
PTM
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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