TPGS1

TPGS1 (Tubulin Polyglutamylase Complex Subunit 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to TPGS1 include microtubule binding and tubulin-glutamic acid ligase activity.

Full Name

Tubulin Polyglutamylase Complex Subunit 1

Function

Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (Probable). May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).

Biological Process

Biological Process adult behavior Source:Ensembl
Biological Process chemical synaptic transmission Source:Ensembl
Biological Process protein polyglutamylation Source:GO_Central1 Publication
Biological Process sperm axoneme assembly Source:Ensembl
Biological Process vesicle localization Source:Ensembl

Cellular Location

Cytoplasm, cytoskeleton, cilium axoneme
Cytoplasm, cytoskeleton, flagellum axoneme
Cytoplasm, cytoskeleton, cilium basal body
Cytoplasm, cytoskeleton, flagellum basal body
Cell projection, axon
Cell projection, dendrite
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Associated with microtubules from neurites, centrosomes, basal bodies and axonemes.