TRAPPC4

TRAPPC4 (Trafficking Protein Particle Complex 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to TRAPPC4 include Rab guanyl-nucleotide exchange factor activity.

Full Name

trafficking protein particle complex 4

Function

Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024).
May play a role in dendrite postsynaptic membrane trafficking (By similarity).

Biological Process

Biological Process autophagy Source:UniProtKB1 Publication
Biological Process COPII vesicle coating Source:ComplexPortal1 Publication
Biological Process dendrite development Source:UniProtKBBy Similarity
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process vesicle coating Source:ComplexPortal1 Publication
Biological Process vesicle tethering Source:ComplexPortal1 Publication

Cellular Location

Postsynaptic cell membrane
Golgi apparatus membrane
Endoplasmic reticulum
Vesicle
Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi).

Involvement in disease

Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy (NEDESBA):
An autosomal recessive disorder characterized by severely impaired global development apparent soon after birth, early-onset seizures, lack of psychomotor development, spastic quadriparesis, progressive cortical and cerebellar atrophy, and dysmorphic features, including microcephaly. Death in childhood may occur.

Anti-TRAPPC4 antibodies

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4558) (CBMAB-T4071-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4558

Application*: WB, IH, IF, F

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4559) (CBMAB-T4072-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-4559

Application*: WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4560) (CBMAB-T4073-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-4560

Application*: WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4561) (CBMAB-T4074-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4561

Application*: WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4562) (CBMAB-T4075-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4562

Application*: E, IC, IF, WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4563) (CBMAB-T4076-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4563

Application*: F, IF, P, WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4564) (CBMAB-T4077-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-4564

Application*: WB, IH, F

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4565) (CBMAB-T4078-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4565

Application*: WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4566) (CBMAB-T4079-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4566

Application*: WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4567) (CBMAB-T4080-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-4567

Application*: F, IF, WB

Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4568) (CBMAB-T4081-YJ)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBYJT-4568

Application*: E, IF, WB

Mouse Anti-TRAPPC4 Recombinant Antibody (2D10) (CBMAB-A9482-LY)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: 2D10

Application*: WB, E

Mouse Anti-TRAPPC4 Recombinant Antibody (2D5) (CBMAB-A9483-LY)

Datasheet

SDS

Target: TRAPPC4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D5

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)