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Mouse Anti-TRAPPC4 Recombinant Antibody (2D5) (CBMAB-A9483-LY)

The product is antibody recognizes TRAPPC4. The antibody 2D5 immunoassay techniques such as: WB, ELISA.
See all TRAPPC4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TRAPPC4 (AAH10866, 1 a.a. ~ 219 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
trafficking protein particle complex 4
Entrez Gene ID
51399
UniProt ID
Q9Y296
Alternative Names
CGI-104; HSPC172; PTD009; SBDN; SYNBINDIN; TRS23
Function
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024).
May play a role in dendrite postsynaptic membrane trafficking (By similarity).
Biological Process
Biological Process autophagy Source:UniProtKB1 Publication
Biological Process COPII vesicle coating Source:ComplexPortal1 Publication
Biological Process dendrite development Source:UniProtKBBy Similarity
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process vesicle coating Source:ComplexPortal1 Publication
Biological Process vesicle tethering Source:ComplexPortal1 Publication
Cellular Location
Postsynaptic cell membrane
Golgi apparatus membrane
Endoplasmic reticulum
Vesicle
Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi).
Involvement in disease
Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy (NEDESBA):
An autosomal recessive disorder characterized by severely impaired global development apparent soon after birth, early-onset seizures, lack of psychomotor development, spastic quadriparesis, progressive cortical and cerebellar atrophy, and dysmorphic features, including microcephaly. Death in childhood may occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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