Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4564) (CBMAB-T4077-YJ)

Name: Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4564)
SKU: CBMAB-T4077-YJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4564

Application

WB, IHC, FC

Immunogen

Full length human recombinant protein of human TRAPPC4(NP_057230) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

trafficking protein particle complex 4

Introduction

TRAPPC4 (Trafficking Protein Particle Complex 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to TRAPPC4 include Rab guanyl-nucleotide exchange factor activity.

Entrez Gene ID

51399

UniProt ID

Q9Y296

Alternative Names

Trafficking Protein Particle Complex 4; Hematopoietic Stem/Progenitor Cell Protein 172; TRS23 Homolog; SYNBINDIN; SBDN; Trafficking Protein Particle Complex Subunit 4

Function

Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024).
May play a role in dendrite postsynaptic membrane trafficking (By similarity).

Biological Process

Biological Process autophagy Source:UniProtKB1 Publication
Biological Process COPII vesicle coating Source:ComplexPortal1 Publication
Biological Process dendrite development Source:UniProtKBBy Similarity
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process vesicle coating Source:ComplexPortal1 Publication
Biological Process vesicle tethering Source:ComplexPortal1 Publication

Cellular Location

Postsynaptic cell membrane
Golgi apparatus membrane
Endoplasmic reticulum
Vesicle
Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi).

Involvement in disease

Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy (NEDESBA):
An autosomal recessive disorder characterized by severely impaired global development apparent soon after birth, early-onset seizures, lack of psychomotor development, spastic quadriparesis, progressive cortical and cerebellar atrophy, and dysmorphic features, including microcephaly. Death in childhood may occur.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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