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Mouse Anti-TRAPPC4 Recombinant Antibody (CBYJT-4567) (CBMAB-T4080-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRAPPC4 (Trafficking Protein Particle Complex 4). The antibody can be used for immunoassay techniques, such as FC, IF, WB.
See all TRAPPC4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4567
Antibody Isotype
IgG2b
Application
FC, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
trafficking protein particle complex 4
Introduction
TRAPPC4 (Trafficking Protein Particle Complex 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to TRAPPC4 include Rab guanyl-nucleotide exchange factor activity.
Entrez Gene ID
51399
UniProt ID
Q9Y296
Alternative Names
Trafficking Protein Particle Complex 4; Hematopoietic Stem/Progenitor Cell Protein 172; TRS23 Homolog; SYNBINDIN; SBDN; Trafficking Protein Particle Complex Subunit 4
Function
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024).
May play a role in dendrite postsynaptic membrane trafficking (By similarity).
Biological Process
Biological Process autophagy Source:UniProtKB1 Publication
Biological Process COPII vesicle coating Source:ComplexPortal1 Publication
Biological Process dendrite development Source:UniProtKBBy Similarity
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process vesicle coating Source:ComplexPortal1 Publication
Biological Process vesicle tethering Source:ComplexPortal1 Publication
Cellular Location
Postsynaptic cell membrane
Golgi apparatus membrane
Endoplasmic reticulum
Vesicle
Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi).
Involvement in disease
Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy (NEDESBA):
An autosomal recessive disorder characterized by severely impaired global development apparent soon after birth, early-onset seizures, lack of psychomotor development, spastic quadriparesis, progressive cortical and cerebellar atrophy, and dysmorphic features, including microcephaly. Death in childhood may occur.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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