TRH

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

Full Name

TRH Gene(Protein Coding) Thyrotropin Releasing Hormone

Function

As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.

Biological Process

Biological Process adult walking behavior Source:Ensembl
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process eating behavior Source:GO_Central1 Publication
Biological Process histamine metabolic process Source:GO_Central1 Publication
Biological Process hormone-mediated signaling pathway Source:InterPro
Biological Process negative regulation of glutamate secretion Source:GO_Central1 Publication
Biological Process positive regulation of gamma-aminobutyric acid secretion Source:GO_Central1 Publication
Biological Process positive regulation of insulin secretion Source:GO_Central1 Publication
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Secreted