Function
Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604, PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31328227, PubMed:31636962, PubMed:31061526).
Together with methyltransferase BUD23, methylates the N7 position of a guanine in 18S rRNA (PubMed:25851604).
The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146, PubMed:31636962, PubMed:31061526).
The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed:31061526).
The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323).
Together with methyltransferase THUMPD3, catalyzes the formation of N2-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (PubMed:34669960).
Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604).
Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:33428944, PubMed:35033535, PubMed:31328227).
Biological Process
Biological Process histone lysine methylation Source:UniProtKB1 Publication
Biological Process peptidyl-glutamine methylation Source:UniProtKB2 Publications
Biological Process positive regulation of rRNA processing Source:UniProtKB1 Publication
Biological Process rRNA (guanine-N7)-methylation Source:UniProtKB1 Publication
Biological Process rRNA methylation Source:UniProtKB2 Publications
Biological Process tRNA methylation Source:GO_Central1 Publication
Biological Process tRNA N2-guanine methylation Source:UniProtKB1 Publication
Cellular Location
Nucleus, nucleoplasm
Cytoplasm, perinuclear region
Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604).
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Datasheet