TSTA3

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq]

Full Name

tissue specific transplantation antigen P35B

Function

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Biological Process

Biological Process 'de novo' GDP-L-fucose biosynthetic process Source:UniProtKB1 Publication
Biological Process GDP-mannose metabolic process Source:UniProtKB1 Publication
Biological Process leukocyte cell-cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell-matrix adhesion via fibronectin Source:UniProtKB1 Publication

Cellular Location

cytosol
extracellular exosome