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Mouse Anti-TSTA3 Recombinant Antibody (CBYJT-5113) (CBMAB-T4691-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TSTA3 (Tissue Specific Transplantation Antigen P35B). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TSTA3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5113
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tissue specific transplantation antigen P35B
Introduction
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. TSTA3 catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in TSTA3 may cause leukocyte adhesion deficiency, type II.
Entrez Gene ID
7264
UniProt ID
Q13630
Alternative Names
Tissue Specific Transplantation Antigen P35B; Short Chain Dehydrogenase/Reductase Family 4E, Member 1; GDP-4-Keto-6-Deoxy-D-Mannose-3, 5-Epimerase-4-Reductase; Red Cell NADP(H)-Binding Protein; GDP-L-Fucose Synthase; EC 1.1.1.271; SDR4E1; Short-Chain Dehydrogenase/Reductase Family 4E Member 1
Function
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Biological Process
Biological Process 'de novo' GDP-L-fucose biosynthetic process Source:UniProtKB1 Publication
Biological Process GDP-mannose metabolic process Source:UniProtKB1 Publication
Biological Process leukocyte cell-cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of endothelial cell-matrix adhesion via fibronectin Source:UniProtKB1 Publication
Cellular Location
cytosol
extracellular exosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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