UCK2

The protein encoded by this gene catalyzes the phosphorylation of uridine monophosphate to uridine diphosphate. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B. [provided by RefSeq]

Full Name

uridine-cytidine kinase 2

Function

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055).
Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702).
Can use ATP or GTP as a phosphate donor (PubMed:11306702).
Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N4-acetylcytidine, N4-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N4-anisoylcytidine (PubMed:11306702).

Biological Process

Biological Process CTP salvage Source:UniProtKB1 Publication
Biological Process phosphorylation Source:UniProtKB-KW
Biological Process UMP salvage Source:UniProtKB1 Publication

Cellular Location

cytoplasm
cytosol