UHMK1

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

U2AF homology motif (UHM) kinase 1

Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).

Biological Process neuron projection development Source:BHF-UCL
Biological Process peptidyl-serine phosphorylation Source:HGNC-UCL1 Publication
Biological Process positive regulation of translational initiation Source:BHF-UCL
Biological Process protein autophosphorylation Source:HGNC-UCL1 Publication
Biological Process regulation of cell cycle Source:HGNC-UCL1 Publication
Biological Process regulation of protein export from nucleus Source:HGNC-UCL1 Publication

Nucleus