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Mouse Anti-UHMK1 Recombinant Antibody (2H4) (CBMAB-K0957-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
2H4
Antibody Isotype
IgG2b
Application
WB, FC, IHC, ICC/IF, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human UHMK1 (NP_787062) produced in HEK293T cell
Specificity
Human, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
U2AF homology motif (UHM) kinase 1
Introduction
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human127933
Monkey720105
UniProt ID
HumanQ8TAS1
MonkeyF7CXW1
Alternative Names
KIS; KIST; P-CIP2
Function
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Biological Process
Biological Process neuron projection development Source:BHF-UCL
Biological Process peptidyl-serine phosphorylation Source:HGNC-UCL1 Publication
Biological Process positive regulation of translational initiation Source:BHF-UCL
Biological Process protein autophosphorylation Source:HGNC-UCL1 Publication
Biological Process regulation of cell cycle Source:HGNC-UCL1 Publication
Biological Process regulation of protein export from nucleus Source:HGNC-UCL1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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