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Mouse Anti-UHMK1 Recombinant Antibody (1H5) (CBMAB-C4568-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H5
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa 1-105 from human UHMK1 (AAH26046) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
U2AF homology motif (UHM) kinase 1
Introduction
The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Entrez Gene ID
127933
UniProt ID
Q8TAS1
Alternative Names
U2AF Homology Motif Kinase 1; PAM COOH-Terminal Interactor Protein 2; U2AF Homology Motif (UHM) Kinase 1; P-CIP2; KIST; KIS;
Function
Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Biological Process
Biological Process neuron projection development Source:BHF-UCL
Biological Process peptidyl-serine phosphorylation Source:HGNC-UCL1 Publication
Biological Process positive regulation of translational initiation Source:BHF-UCL
Biological Process protein autophosphorylation Source:HGNC-UCL1 Publication
Biological Process regulation of cell cycle Source:HGNC-UCL1 Publication
Biological Process regulation of protein export from nucleus Source:HGNC-UCL1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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