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UNC13B

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]
Full Name
Unc-13 Homolog B
Function
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity).
Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).
Biological Process
Biological Process acrosomal vesicle exocytosis Source:UniProtKB1 Publication
Biological Process cellular response to glucose stimulus Source:ParkinsonsUK-UCL1 Publication
Biological Process chemical synaptic transmission Source:ParkinsonsUK-UCL
Biological Process dense core granule priming Source:GO_Central1 Publication
Biological Process neuromuscular junction development Source:GO_Central1 Publication
Biological Process neuronal dense core vesicle exocytosis Source:UniProtKB
Biological Process positive regulation of apoptotic process Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of inhibitory postsynaptic potential Source:ParkinsonsUK-UCL
Biological Process positive regulation of protein secretion Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of synaptic vesicle priming Source:ParkinsonsUK-UCL
Biological Process presynaptic dense core vesicle exocytosis Source:GO_Central1 Publication
Biological Process synaptic transmission, glutamatergic Source:GO_Central1 Publication
Biological Process synaptic vesicle docking Source:GO_Central1 Publication
Biological Process synaptic vesicle maturation Source:GO_Central1 Publication
Biological Process synaptic vesicle priming Source:ParkinsonsUK-UCL
Cellular Location
Cytoplasm
Membrane
Cell membrane
Synapse
Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity).

Anti-UNC13B antibodies

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Target: UNC13B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: 32/panMunc13
Application*: WB, IF
Target: UNC13B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 584102
Application*: IH
Target: UNC13B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-3177
Application*: E, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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