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USP39

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity, but could be a competitor of ubiquitin C-terminal hydrolases (UCHs).

Full Name

ubiquitin specific peptidase 39

Function

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367).
Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity (PubMed:18728397).

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process mRNA processing Source:ProtInc1 Publication
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:InterPro
Biological Process RNA splicing Source:ProtInc1 Publication
Biological Process spliceosomal complex assembly Source:UniProtKB1 Publication

Cellular Location

Nucleus

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Anti-USP39 antibodies

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Mouse Anti-USP39 Recombinant Antibody (4G11) (CBMAB-A9829-LY)

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Target: USP39

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4G11

Application*: WB, E

Rabbit Anti-USP39 Recombinant Antibody (CBXU-036) (CBMAB-U0152-CQ)

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Target: USP39

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXU-036

Application*: WB, P, IC

Rabbit Anti-USP39 Recombinant Antibody (CBXU-035) (CBMAB-U0151-CQ)

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Target: USP39

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBXU-035

Application*: WB, P, IC

Mouse Anti-USP39 Recombinant Antibody (3205C5a) (CBMAB-U0060-CQ)

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Target: USP39

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3205C5a

Application*: DB, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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