VNN1

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq]
Full Name
vanin 1
Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Biological Process
Biological Process acute inflammatory response Source:BHF-UCLBy Similarity
Biological Process cell-cell adhesion Source:BHF-UCLBy Similarity
Biological Process chronic inflammatory response Source:BHF-UCLBy Similarity
Biological Process inflammatory response Source:BHF-UCLBy Similarity
Biological Process innate immune response Source:BHF-UCLBy Similarity
Biological Process pantothenate metabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source:BHF-UCLBy Similarity
Biological Process positive regulation of T cell differentiation in thymus Source:BHF-UCLBy Similarity
Biological Process response to oxidative stress Source:BHF-UCL1 Publication
Cellular Location
Cell membrane
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Anti-VNN1 antibodies

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Mouse Anti-VNN1 Recombinant Antibody (2B10) (CBMAB-A9887-LY)

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Target: VNN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B10
Application*: IF, E
Datasheet SDS

Mouse Anti-VNN1 Recombinant Antibody (4E11) (CBMAB-A9886-LY)

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Target: VNN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E11
Application*: IP, E
Datasheet SDS

Mouse Anti-VNN1 Recombinant Antibody (CBYC-P863) (CBMAB-P3785-YC)

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Target: VNN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P863
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-VNN1 Recombinant Antibody (CBYC-P862) (CBMAB-P3784-YC)

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Target: VNN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P862
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-VNN1 Recombinant Antibody (CBYY-1582) (CBMAB-1652-YY)

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Target: VNN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-1582
Application*: IP, SE, E
Datasheet SDS

Rat Anti-VNN1 Recombinant Antibody (CBYY-1521) (CBMAB-1591-YY)

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Target: VNN1
Host: Rat
Specificity: Mouse
Clone: CBYY-1521
Application*: WB, IP, IF, F
Datasheet SDS

Human VNN1 ELISA Kit (V2LY-0626-LY4997)

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Target: VNN1
Sensitivity: 0.015 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Vnn1 ELISA Kit (V2LY-0626-LY2839)

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Target: Vnn1
Sensitivity: 0.0073 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human Recombinant VNN1 protein, His Tag (V2LY-0526-LY7581)

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Target: VNN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-490
Tag: His Tag
Datasheet SDS

Mouse Recombinant VNN1 protein, His Tag (V2LY-0526-LY9052)

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Target: VNN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-487
Tag: His Tag
Datasheet SDS

Mouse Recombinant VNN1 protein, hFc Tag (V2LY-0526-LY9051)

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Target: VNN1
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-487
Tag: hFc Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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