Mouse Anti-VNN1 Recombinant Antibody (4E11) (CBMAB-A9886-LY)

Name: Mouse Anti-VNN1 Recombinant Antibody (4E11)
SKU: CBMAB-A9886-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4E11

Application

IP, ELISA

Immunogen

VNN1 (NP_004657, 298 a.a. ~ 397 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

vanin 1

Introduction

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq]

Entrez Gene ID

8876

UniProt ID

O95497

Alternative Names

HDLCQ8; MGC116930; MGC116931; MGC116932; MGC116933; Tiff66

Function

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

Biological Process

Biological Process acute inflammatory response Source:BHF-UCLBy Similarity
Biological Process cell-cell adhesion Source:BHF-UCLBy Similarity
Biological Process chronic inflammatory response Source:BHF-UCLBy Similarity
Biological Process inflammatory response Source:BHF-UCLBy Similarity
Biological Process innate immune response Source:BHF-UCLBy Similarity
Biological Process pantothenate metabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source:BHF-UCLBy Similarity
Biological Process positive regulation of T cell differentiation in thymus Source:BHF-UCLBy Similarity
Biological Process response to oxidative stress Source:BHF-UCL1 Publication

Cellular Location

Cell membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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