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Mouse Anti-VNN1 Recombinant Antibody (CBYC-P863) (CBMAB-P3785-YC)

Provided herein is a Mouse monoclonal antibody against Human Vanin 1. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all VNN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P863
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Vanin 1
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, containing 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
vanin 1
Introduction
VNN1 is a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.
Entrez Gene ID
8876
UniProt ID
O95497
Alternative Names
HDLCQ8; Tiff66
Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Biological Process
Biological Process acute inflammatory response Source:BHF-UCLBy Similarity
Biological Process cell-cell adhesion Source:BHF-UCLBy Similarity
Biological Process chronic inflammatory response Source:BHF-UCLBy Similarity
Biological Process inflammatory response Source:BHF-UCLBy Similarity
Biological Process innate immune response Source:BHF-UCLBy Similarity
Biological Process pantothenate metabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source:BHF-UCLBy Similarity
Biological Process positive regulation of T cell differentiation in thymus Source:BHF-UCLBy Similarity
Biological Process response to oxidative stress Source:BHF-UCL1 Publication
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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