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VSTM1

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

Full Name

Vascular Cell Adhesion Molecule 1

Function

Isoform 2
Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Isoform 1
Inhibitory immune receptor involved in the regulation of phagocytes.

Biological Process

Biological Process immune system process Source:UniProtKB-KW

Cellular Location

Isoform 1
Membrane
Isoform 2
Secreted

Topology

Extracellular: 17-135
Helical: 136-156
Cytoplasmic: 157-236

PTM

Isoform 2 is N-glycosylated.

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Anti-VSTM1 antibodies

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Mouse Anti-VSTM1 Recombinant Antibody (CBFYA-0276) (CBMAB-X0406-FY)

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Target: VSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYA-0276

Application*: F, FN, IP, WB

Recombinant Mouse Anti-VSTM1 Antibody (CBHb325) (CBMAB-Hb973-LY)

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Target: VSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb325

Application*: FC, FuncS, IP, WB

Mouse Anti-VSTM1 Recombinant Antibody (2E12) (CBMAB-A9899-LY)

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Target: VSTM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E12

Application*: WB, E

Mouse Anti-VSTM1 Recombinant Antibody (CBXS-3814) (CBMAB-S1085-CQ)

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Target: VSTM1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-3814

Application*: F, FN, IP

Rabbit Anti-VSTM1 Recombinant Antibody (104) (CBMAB-V0080-YC)

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Target: VSTM1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 104

Application*: E

Human Recombinant VSTM1 protein, His Tag (V2LY-0526-LY7659)

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Target: VSTM1

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-135

Tag: His Tag

Human Recombinant VSTM1 protein, hFc Tag (V2LY-0526-LY7658)

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Target: VSTM1

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-135

Tag: hFc Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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