WDR18

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

Full Name

WD Repeat Domain 18

Function

Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859).
Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211).
May play a role during development (By similarity).

Biological Process

Biological Process DNA-templated DNA replication Source:GO_Central1 Publication
Biological Process rRNA processing Source:GO_Central1 Publication

Cellular Location

Nucleus, nucleolus
Nucleus, nucleoplasm
Cytoplasm
Dynein axonemal particle
Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.