WDR59

WDR59 (WD Repeat Domain 59) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signaling pathway (KEGG). An important paralog of this gene is WDR24.

Full Name

WD Repeat Domain 59

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).

Biological Process

Biological Process cellular response to amino acid starvation Source:UniProtKB1 Publication
Biological Process negative regulation of TORC1 signaling Source:ComplexPortal1 Publication
Biological Process positive regulation of TOR signaling Source:SGD1 Publication
Biological Process positive regulation of TORC1 signaling Source:GO_Central1 Publication

Cellular Location

Lysosome membrane

Anti-WDR59 antibodies

Rabbit Anti-WDR59 Recombinant Antibody (CBWJW-010) (CBMAB-W0167-WJ)

Datasheet

SDS

Target: WDR59

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBWJW-010

Application*: WB, IP

Rabbit Anti-WDR59 Recombinant Antibody (D4Z7A) (CBMAB-CP3012-LY)

Datasheet

SDS

Target: WDR59

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: D4Z7A

Application*: WB, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)