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WDR59

WDR59 (WD Repeat Domain 59) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signaling pathway (KEGG). An important paralog of this gene is WDR24.

Full Name

WD Repeat Domain 59

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).

Biological Process

Biological Process cellular response to amino acid starvation Source:UniProtKB1 Publication
Biological Process negative regulation of TORC1 signaling Source:ComplexPortal1 Publication
Biological Process positive regulation of TOR signaling Source:SGD1 Publication
Biological Process positive regulation of TORC1 signaling Source:GO_Central1 Publication

Cellular Location

Lysosome membrane

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Anti-WDR59 antibodies

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Rabbit Anti-WDR59 Recombinant Antibody (D4Z7A) (CBMAB-CP3012-LY)

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Target: WDR59

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: D4Z7A

Application*: WB, IP

Rabbit Anti-WDR59 Recombinant Antibody (CBWJW-010) (CBMAB-W0167-WJ)

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Target: WDR59

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBWJW-010

Application*: WB, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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