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Rabbit Anti-WDR59 Recombinant Antibody (D4Z7A) (CBMAB-CP3012-LY)

The product is antibody recognizes WDR59. The antibody D4Z7A immunoassay techniques such as: WB,IP.
See all WDR59 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D4Z7A
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His356 of human WDR59 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
WD Repeat Domain 59
Introduction
WDR59 (WD Repeat Domain 59) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signaling pathway (KEGG). An important paralog of this gene is WDR24.
Entrez Gene ID
Human79726
Monkey710576
UniProt ID
HumanQ6PJI9
MonkeyF7EZS6
Alternative Names
WD Repeat Domain 59; WD Repeat-Containing Protein 59; GATOR Complex Protein WDR59; CDw12 Antigen; KIAA1923; P90-120; CDW12; FP977;
Function
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Biological Process
Biological Process cellular response to amino acid starvation Source:UniProtKB1 Publication
Biological Process negative regulation of TORC1 signaling Source:ComplexPortal1 Publication
Biological Process positive regulation of TOR signaling Source:SGD1 Publication
Biological Process positive regulation of TORC1 signaling Source:GO_Central1 Publication
Cellular Location
Lysosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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