Rabbit Anti-WDR59 Recombinant Antibody (D4Z7A) (CBMAB-CP3012-LY)

Name: Rabbit Anti-WDR59 Recombinant Antibody (D4Z7A)
SKU: CBMAB-CP3012-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D4Z7A

Application

WB, IP

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His356 of human WDR59 protein.

Specificity

Human, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

WD Repeat Domain 59

Introduction

WDR59 (WD Repeat Domain 59) is a Protein Coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signaling pathway (KEGG). An important paralog of this gene is WDR24.

Entrez Gene ID

Human	79726
Monkey	710576

UniProt ID

Human	Q6PJI9
Monkey	F7EZS6

Alternative Names

WD Repeat Domain 59; WD Repeat-Containing Protein 59; GATOR Complex Protein WDR59; CDw12 Antigen; KIAA1923; P90-120; CDW12; FP977;

Function

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).

Biological Process

Biological Process cellular response to amino acid starvation Source:UniProtKB1 Publication
Biological Process negative regulation of TORC1 signaling Source:ComplexPortal1 Publication
Biological Process positive regulation of TOR signaling Source:SGD1 Publication
Biological Process positive regulation of TORC1 signaling Source:GO_Central1 Publication

Cellular Location

Lysosome membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-WDR59 Recombinant Antibody (CBWJW-010) (CAT#: CBMAB-W0167-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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