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Rabbit Anti-WDR59 Recombinant Antibody (CBWJW-010) (CBMAB-W0167-WJ)

This product is a rabbit antibody that recognizes WDR59. The antibody CBWJW-010 can be used for immunoassay techniques such as: WB, IP.
See all WDR59 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBWJW-010
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WD Repeat Domain 59
Introduction
WDR59 is a protein-coding gene. Among its related pathways are PI3K / Akt Signaling and mTOR signaling pathway (KEGG). WDR24 is an important paralog of this gene.
Entrez Gene ID
Human79726
Monkey710576
UniProt ID
HumanQ6PJI9
MonkeyF7EZS6
Alternative Names
CDW12; FP977; p90-120
Function
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238).
It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Biological Process
Biological Process cellular response to amino acid starvation Source:UniProtKB1 Publication
Biological Process negative regulation of TORC1 signaling Source:ComplexPortal1 Publication
Biological Process positive regulation of TOR signaling Source:SGD1 Publication
Biological Process positive regulation of TORC1 signaling Source:GO_Central1 Publication
Cellular Location
Lysosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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