WWC1

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.

Full Name

WW And C2 Domain Containing 1

Function

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

Biological Process

Biological Process cell migration Source:UniProtKB1 Publication
Biological Process establishment of cell polarity Source:BHF-UCL1 Publication
Biological Process negative regulation of hippo signaling Source:BHF-UCL1 Publication
Biological Process negative regulation of organ growth Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of MAPK cascade Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process regulation of hippo signaling Source:UniProtKB1 Publication
Biological Process regulation of intracellular transport Source:BHF-UCL1 Publication

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Cell projection, ruffle membrane
Colocalizes with PRKCZ in the perinuclear region.

PTM

Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.