Mouse Anti-WWC1 Recombinant Antibody (1B1) (CBMAB-W0030-WJ)

Name: Mouse Anti-WWC1 Recombinant Antibody (1B1)
SKU: CBMAB-W0030-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1B1

Application

Immunogen

Full length human recombinant protein of human WWC1 (NP_056053) produced in HEK293T cell.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WW And C2 Domain Containing 1

Introduction

WWC1 is a protein-coding gene encodes the protein which is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Diseases associated with WWC1 include Memory Quantitative Trait Locus. An important paralog of this gene is WWC2.

Entrez Gene ID

23286

UniProt ID

Q8IX03

Alternative Names

KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168

Function

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

Biological Process

Biological Process cell migration Source:UniProtKB1 Publication
Biological Process establishment of cell polarity Source:BHF-UCL1 Publication
Biological Process negative regulation of hippo signaling Source:BHF-UCL1 Publication
Biological Process negative regulation of organ growth Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of MAPK cascade Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process regulation of hippo signaling Source:UniProtKB1 Publication
Biological Process regulation of intracellular transport Source:BHF-UCL1 Publication

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Cell projection, ruffle membrane
Colocalizes with PRKCZ in the perinuclear region.

PTM

Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-WWC1 Recombinant Antibody (1H8) (CAT#: CBMAB-W0053-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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