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Mouse Anti-WWC1 Recombinant Antibody (1H8) (CBMAB-W0053-WJ)

This product is a mouse antibody that recognizes WWC1. The antibody 1H8 can be used for immunoassay techniques such as: WB.
See all WWC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H8
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human WWC1 (NP_056053) produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
6.39 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
WW And C2 Domain Containing 1
Introduction
WWC1 is a protein-coding gene encodes the protein which is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Diseases associated with WWC1 include Memory Quantitative Trait Locus. An important paralog of this gene is WWC2.
Entrez Gene ID
23286
UniProt ID
Q8IX03
Alternative Names
KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168
Function
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.
Biological Process
Biological Process cell migration Source:UniProtKB1 Publication
Biological Process establishment of cell polarity Source:BHF-UCL1 Publication
Biological Process negative regulation of hippo signaling Source:BHF-UCL1 Publication
Biological Process negative regulation of organ growth Source:BHF-UCL1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of MAPK cascade Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process regulation of hippo signaling Source:UniProtKB1 Publication
Biological Process regulation of intracellular transport Source:BHF-UCL1 Publication
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Cell projection, ruffle membrane
Colocalizes with PRKCZ in the perinuclear region.
PTM
Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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