XRCC3

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq]

X-ray repair complementing defective repair in Chinese hamster cells 3

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Biological Process cellular response to DNA damage stimulus Source:ProtInc1 Publication
Biological Process DNA recombination Source:ProtInc1 Publication
Biological Process DNA repair Source:BHF-UCL1 Publication
Biological Process double-strand break repair via homologous recombination Source:UniProtKB1 Publication
Biological Process double-strand break repair via synthesis-dependent strand annealing Source:GO_Central1 Publication
Biological Process interstrand cross-link repair Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of mitotic cell cycle spindle assembly checkpoint Source:UniProtKB1 Publication
Biological Process regulation of centrosome duplication Source:UniProtKB1 Publication
Biological Process resolution of mitotic recombination intermediates Source:UniProtKB1 Publication
Biological Process response to organic substance Source:Ensembl
Biological Process t-circle formation Source:BHF-UCL1 Publication
Biological Process telomere maintenance via recombination Source:BHF-UCL1 Publication
Biological Process telomere maintenance via telomere trimming Source:BHF-UCL1 Publication
Biological Process telomeric loop disassembly Source:BHF-UCL1 Publication

Nucleus
Cytoplasm
Cytoplasm, perinuclear region
Mitochondrion
Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

Breast cancer (BC):
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Melanoma, cutaneous malignant 6 (CMM6):
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites.