YIPF3

YIPF3 (Yip1 Domain Family Member 3) is a Protein Coding gene. Diseases associated with YIPF3 include Frasier Syndrome.

Full Name

Yip1 domain family, member 3

Function

Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.

Biological Process

Biological Process cell differentiation Source:UniProtKB-KW

Cellular Location

Cell membrane
Cytoplasm
Golgi apparatus, cis-Golgi network membrane
Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.

Topology

Cytoplasmic: 2-148
Helical: 149-169
Lumenal: 170-187
Helical: 188-208
Cytoplasmic: 209-214
Helical: 215-237
Lumenal: 238-240
Helical: 241-263
Cytoplasmic: 264-274
Helical: 275-295
Lumenal: 296-350

PTM

N-glycosylated in the ER (40 kDa form I), then O-glycosylated in the Golgi apparatus (46 kDa form II), the C-terminal lumenal region is later removed in the Golgi apparatus to produce a 36 kDa form III. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Thr-346: HexNAc (minor), HexHexNAc (major), Hex1HexNAc2 (minor), Hex2HexNAc2 (minor) and dHex1Hex2HexNAc2 (minor).