ZBTB7A

Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5-[GA][CA]GACCCCCCCCC-3 (By similarity).

Zinc Finger And BTB Domain Containing 7A

Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381).
Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381).
Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493).
That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493).
Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity).
Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059).
Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024).
Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).
Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381).
Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381).
Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity).
Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity).
Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity).
Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326).
Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838).
Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity).
Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity).
Also regulates osteoclast differentiation (By similarity).
May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity).
Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity).
May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149).

Biological Process B cell differentiation Source:UniProtKB
Biological Process chromatin organization Source:UniProtKB
Biological Process chromatin remodeling Source:UniProtKB1 Publication
Biological Process double-strand break repair via classical nonhomologous end joining Source:UniProtKB
Biological Process erythrocyte maturation Source:UniProtKB1 Publication
Biological Process fat cell differentiation Source:UniProtKB1 Publication
Biological Process negative regulation of androgen receptor signaling pathway Source:UniProtKB1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of Notch signaling pathway Source:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein localization to nucleus Source:UniProtKB1 Publication
Biological Process regulation of alternative mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process regulation of DNA-binding transcription factor activity Source:UniProtKB
Biological Process regulation of glycolytic process Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central2 Publications
Biological Process regulation of transcription regulatory region DNA binding Source:UniProtKB1 Publication

Nucleus
Recruited to double-strand break sites of damaged DNA.

Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin (MNDLFH):
An autosomal dominant disease characterized by pharyngeal lymphoid hypertrophy, with adenoid overgrowth, sleep apnea, macrocephaly without structural brain abnormalities, and impaired intellectual development. An increased fraction of fetal hemoglobin has been observed in some patients.

Sumoylated. Undergoes sumoylation with SUMO1 that may regulate its transcriptional activity.