ZGPAT

Transcription repressor that specifically binds the 5-GGAG[GA]A[GA]A-3 consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.

Full Name

zinc finger CCCH-type and G-patch domain containing

Function

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.
Isoform 4
Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.

Biological Process

Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of epidermal growth factor-activated receptor activity Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Cellular Location

Nucleus
Isoform 4
Nucleus

PTM

Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP.