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ZWILCH

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).

Full Name

Zwilch, kinetochore associated, homolog (Drosophila)

Function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).

Biological Process

Biological Process cell division Source:UniProtKB-KW
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB1 Publication
Biological Process protein localization to kinetochore Source:UniProtKB1 Publication

Cellular Location

Chromosome, centromere, kinetochore

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Anti-ZWILCH antibodies

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Rabbit Anti-ZWILCH Recombinant Antibody (CBWJZ-306) (CBMAB-Z0794-WJ)

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Target: ZWILCH

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJZ-306

Application*: WB, IP

Mouse Anti-ZWILCH Recombinant Antibody (1C9) (CBMAB-Z0793-WJ)

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Target: ZWILCH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C9

Application*: E, WB

Mouse Anti-ZWILCH Recombinant Antibody (1C10) (CBMAB-Z0792-WJ)

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Target: ZWILCH

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C10

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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