ZWINT

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
ZW10 Interacting Kinetochore Protein
Function
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Biological Process
Biological Process cell division Source:UniProtKB-KW
Biological Process establishment of localization in cell Source:HGNC-UCL1 Publication
Biological Process mitotic sister chromatid segregation Source:HGNC-UCL1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:HGNC-UCL1 Publication
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Note: Localizes to kinetochores from late prophase to anaphase.
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Anti-ZWINT antibodies

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Mouse Anti-ZWINT Recombinant Antibody (1B7) (CBMAB-Z0797-WJ)

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Target: ZWINT
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1B7
Application*: E, WB
Datasheet SDS

Mouse Anti-ZWINT Recombinant Antibody (6D3) (CBMAB-Z0796-WJ)

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Target: ZWINT
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6D3
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ZWINT Recombinant Antibody (422CT4.6.4) (CBMAB-Z0795-WJ)

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Target: ZWINT
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: 422CT4.6.4
Application*: E, WB
Datasheet SDS

ZWINT Matched Antibody Pair (1337) (APMAB-1337LY)

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Target: ZWINT
Specificity: Human
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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