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Mouse Anti-ZWINT Recombinant Antibody (422CT4.6.4) (CBMAB-Z0795-WJ)

This product is a mouse antibody that recognizes ZWINT. The antibody 422CT4.6.4 can be used for immunoassay techniques such as: ELISA, WB.
See all ZWINT antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
422CT4.6.4
Antibody Isotype
IgM
Application
ELISA, WB

Basic Information

Immunogen
Purified His-tagged ZWINT protein(Fragment).
Specificity
Human, Mouse
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
2 mg/mL

Target

Full Name
ZW10 Interacting Kinetochore Protein
Introduction
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human11130
Mouse52696
UniProt ID
HumanO95229
MouseQ9CQU5
Alternative Names
SIP30; ZWINT1; KNTC2AP; HZwint-1
Function
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Biological Process
Biological Process cell division Source:UniProtKB-KW
Biological Process establishment of localization in cell Source:HGNC-UCL1 Publication
Biological Process mitotic sister chromatid segregation Source:HGNC-UCL1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:HGNC-UCL1 Publication
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Note: Localizes to kinetochores from late prophase to anaphase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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