ACTN4 Matched Antibody Pair (013) (APMAB-013LY)

Name: ACTN4 Matched Antibody Pair (013)
SKU: APMAB-013LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Mouse anti-ACTN4 monoclonal, IgG1 antibody, 100 ug

Detection Antibody

Anti-ACTN4 Biotinylated mouse monoclonal, IgG2b antibody, 50 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

Alternative Names

Actinin Alpha 4; Focal Segmental Glomerulosclerosis 1; Non-Muscle Alpha-Actinin 4; Alpha-Actinin-4; ACTININ-4; FSGS1; FSGS;

Entrez Gene ID

UniProt ID

O43707

More Infomation

Shao, H., & Wells, A. (2021). Binding of alpha-ACTN4 to EGF receptor enables its rapid phosphorylation. Heliyon, 7(1), e06011.

Xing, Z., Li, S., Liu, Z., Zhang, C., & Bai, Z. (2020). CTCF‐induced upregulation of HOXA11‐AS facilitates cell proliferation and migration by targeting miR‐518b/ACTN4 axis in prostate cancer. The Prostate, 80(5), 388-398.

Ishizuya, Y., Uemura, M., Narumi, R., Tomiyama, E., Koh, Y., Matsushita, M., ... & Nonomura, N. (2020). The role of actinin-4 (ACTN4) in exosomes as a potential novel therapeutic target in castration-resistant prostate cancer. Biochemical and biophysical research communications, 523(3), 588-594.

Lin, Y. H., Huang, C. Y., Ke, C. C., Wang, Y. Y., Lai, T. H., Liu, H. C., ... & Lin, Y. H. (2020). ACTN4 mediates SEPT14 mutation-induced sperm head defects. Biomedicines, 8(11), 518.

Tentler, D., Lomert, E., Novitskaya, K., & Barlev, N. A. (2019). Role of ACTN4 in Tumorigenesis, Metastasis, and EMT. Cells, 8(11), 1427.

Ji, J., Xu, R., Ding, K., Bao, G., Zhang, X., Huang, B., ... & Wang, J. (2019). Long noncoding RNA SChLAP1 forms a growth-promoting complex with HNRNPL in human glioblastoma through stabilization of ACTN4 and activation of NF-κB signaling. Clinical Cancer Research, 25(22), 6868-6881.

Zhao, J., Peng, W., Ran, Y., Ge, H., Zhang, C., Zou, H., ... & Qi, H. (2019). Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia. Journal of physiology and biochemistry, 75(4), 475-487.

Zhang, Y. Y., Tabataba, H., Liu, X. Y., Wang, J. Y., Yan, X. G., Farrelly, M., ... & Jin, L. (2018). ACTN4 regulates the stability of RIPK1 in melanoma. Oncogene, 37(29), 4033-4045.

Lomert, E., Turoverova, L., Kriger, D., Aksenov, N. D., Nikotina, A. D., Petukhov, A., ... & Tentler, D. (2018). Co-expression of RelA/p65 and ACTN4 induces apoptosis in non-small lung carcinoma cells. Cell Cycle, 17(5), 616-626.

Kakuya, T., Mori, T., Yoshimoto, S., Watabe, Y., Miura, N., Shoji, H., ... & Honda, K. (2017). Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer. International journal of oral and maxillofacial surgery, 46(8), 968-976.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

ACTN4 Matched Antibody Pair (011) (CAT#: APMAB-011LY)

ACTN4 Matched Antibody Pair (012) (CAT#: APMAB-012LY)

ACTN4 Matched Antibody Pair (014) (CAT#: APMAB-014LY)

ACTN4 Matched Antibody Pair (015) (CAT#: APMAB-015LY)

ACTN4 Matched Antibody Pair (016) (CAT#: APMAB-016LY)

Antibody Pairs

ACTN4 Matched Antibody Pair (011) (CAT#: APMAB-011LY)

ACTN4 Matched Antibody Pair (012) (CAT#: APMAB-012LY)

ACTN4 Matched Antibody Pair (014) (CAT#: APMAB-014LY)

ACTN4 Matched Antibody Pair (015) (CAT#: APMAB-015LY)

ACTN4 Matched Antibody Pair (016) (CAT#: APMAB-016LY)

Related Products

ACTN4 Matched Antibody Pair (012) (CAT#: APMAB-012LY)

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ACTN4 Matched Antibody Pair (011) (CAT#: APMAB-011LY)

Rabbit Anti-ACTN4 Recombinant Antibody (V2-630610) (CAT#: CBMAB-BR009LY)

ACTN4 Matched Antibody Pair (015) (CAT#: APMAB-015LY)

Mouse Anti-ACTN4 Recombinant Antibody (V2-6075) (CAT#: CBMAB-0020CQ)

ACTN4 Matched Antibody Pair (014) (CAT#: APMAB-014LY)

Mouse Anti-ACTN4 Recombinant Antibody (V2-610951) (CAT#: CBMAB-A0094-LY)

Mouse Anti-ACTN4 Recombinant Antibody (V2-12514) (CAT#: CBMAB-1004-CN)

ACTN4 Matched Antibody Pair (016) (CAT#: APMAB-016LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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