Mouse Anti-ACOT7 Recombinant Antibody (V2-179345) (CBMAB-A0646-YC)

Name: Mouse Anti-ACOT7 Recombinant Antibody (V2-179345)
SKU: CBMAB-A0646-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179345

Application

WB, FC, ELISA, ICC, IF

Immunogen

Recombinant human ACOT7 (1-370 aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IF(ICC)	1:100
ELISA	1:100-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4, 10% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Acyl-CoA Thioesterase 7

Introduction

ACOT7 is a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively splice

Entrez Gene ID

11332

UniProt ID

O00154

Alternative Names

Acyl-CoA Thioesterase 7; Long Chain Acyl-CoA Thioester Hydrolase; Brain Acyl-CoA Hydrolase; EC 3.1.2.2; CTE-IIa; CTE-II; BACH; Cytosolic Acyl Coenzyme A Thioester Hydrolase; Acyl-CoA Thioesterase, Long Chain;

Function

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.

Biological Process

Acyl-CoA metabolic process
Coenzyme A biosynthetic process
Fatty acid metabolic process
Long-chain fatty-acyl-CoA catabolic process
Medium-chain fatty acid biosynthetic process
Medium-chain fatty-acyl-CoA catabolic process
Palmitic acid biosynthetic process

Cellular Location

Isoform 1: Mitochondrion
Isoform 4: Cytosol
Isoform 5: Mitochondrion
Isoform 6: Cytosol

Feng, H., & Liu, X. (2020). Interaction between ACOT7 and LncRNA NMRAL2P via methylation regulates gastric cancer progression. Yonsei Medical Journal, 61(6), 471.

Bowman, C. E., Selen Alpergin, E. S., Ellis, J. M., & Wolfgang, M. J. (2019). Loss of ACOT7 potentiates seizures and metabolic dysfunction. American Journal of Physiology-Endocrinology and Metabolism, 317(5), E941-E951.

Bakshi, I., Brown, S. H., Brandon, A. E., Suryana, E., Mitchell, T. W., Turner, N., & Cooney, G. J. (2018). Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats. Scientific reports, 8(1), 1-12.

Jung, S. H., Lee, H. C., Hwang, H. J., Park, H. A., Moon, Y. A., Kim, B. C., ... & Lee, J. S. (2017). Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKC ζ–p53–p21 signaling pathway. Cell death & disease, 8(5), e2793-e2793.

Wall, V. Z., Barnhart, S., Kramer, F., Kanter, J. E., Vivekanandan-Giri, A., Pennathur, S., ... & Bornfeldt, K. E. (2017). Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥ C20)-acyl chains in macrophages [S]. Journal of lipid research, 58(6), 1174-1185.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-ACOT7 Recombinant Antibody (V2-179344) (CAT#: CBMAB-A0645-YC)

Mouse Anti-ACOT7 Recombinant Antibody (V2-179346) (CAT#: CBMAB-A0647-YC)

Mouse Anti-ACOT7 Recombinant Antibody (V2-179347) (CAT#: CBMAB-A0648-YC)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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