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Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859)


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Tested Data
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in WB
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in WB
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in WB
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in WB
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in WB
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in WB
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in FC
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in FC
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in ELISA
Mouse Anti-ACP5 Recombinant Antibody (CBT2906) (V2LY-0625-LY2859) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2906
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human ACP5 (AA: 221-325) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
54
UniProt ID
P13686
Function
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Biological Process
Bone resorption
Ossification
Riboflavin metabolic process
Cellular Location
Lysosome
Involvement in disease
Spondyloenchondrodysplasia with immune dysregulation (SPENCDI): A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone.
More Infomation

Shakya, M., Raizada, S., Yadav, R., & Singh, P. (2021). Computational Fine-Tuning of Functional Single Nucleotide Polymorphisms Associated with ACP5 Gene to Characterize Missense Mutations Running Title: SNP Analysis of ACP5 Gene.

Hu, Y., Yu, J., Wang, Q., Zhang, L., Chen, X., Cao, Y., ... & Xiong, W. (2020). Tartrate-resistant acid phosphatase 5/ACP5 interacts with p53 to control the expression of SMAD3 in lung adenocarcinoma. Molecular Therapy-Oncolytics, 16, 272-288.

Bai, X., He, C., Fu, B., Kong, X., Bu, J., Zhu, K., ... & Ni, B. (2020). microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity. Cell Cycle, 19(23), 3260-3276.

Hu, Y., Yu, J., Wang, Q., Zhou, Q., Deng, Y., Liu, J., ... & Wang, Y. (2020). Tartrate-resistant acid phosphatase 5 serves as a viable target against pulmonary fibrosis by modulating β-catenin signaling.

Ramesh, J., Parthasarathy, L. K., Janckila, A. J., Begum, F., Murugan, R., Murthy, B. P., ... & Venugopal, B. (2020). Characterisation of ACP5 missense mutations encoding tartrate-resistant acid phosphatase associated with spondyloenchondrodysplasia. PloS one, 15(3), e0230052.

Huang, Y., Wang, L., Mao, Y., & Nan, G. (2019). Long noncoding RNA-H19 contributes to atherosclerosis and induces ischemic stroke via the upregulation of acid phosphatase 5. Frontiers in neurology, 10, 32.

He, C., Bai, X., Li, Y., Sun, H., Kong, X., Fu, B., ... & Xu, S. (2019). Runt-related transcription factor 1 contributes to lung cancer development by binding to tartrate-resistant acid phosphatase 5. Cell Cycle, 18(23), 3404-3419.

Reithmeier, A., Lundbäck, T., Haraldsson, M., Frank, M., Ek‐Rylander, B., Nyholm, P. G., ... & Andersson, G. (2018). Identification of inhibitors of Tartrate‐resistant acid phosphatase (TRAP/ACP 5) activity by small‐molecule screening. Chemical biology & drug design, 92(1), 1255-1271.

Gao, Y. L., Liu, M. R., Yang, S. X., Dong, Y. J., & Tan, X. F. (2018). Prognostic significance of ACP5 expression in patients with lung adenocarcinoma. The clinical respiratory journal, 12(3), 1100-1105.

Ren, X., Shan, W. H., Wei, L. L., Gong, C. C., & Pei, D. S. (2018). ACP5: Its structure, distribution, regulation and novel functions. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 18(8), 1082-1090.

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For research use only. Not intended for any clinical use.

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