Mouse Recombinant ACP5 protein, His Tag (V2LY-0526-LY7770)

Name: Mouse Recombinant ACP5 protein, His Tag
SKU: V2LY-0526-LY7770
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant ACP5 protein, His Tag consist of Amino Acid: 1-327 and predicts a molecular mass of 35.8 kDa.

Molecule Mass

35.8 kDa

Sequence

Amino Acid: 1-327

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Acid Phosphatase 5, Tartrate Resistant

Function

Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Biological Process

Bone resorption
Ossification
Riboflavin metabolic process

Cellular Location

Lysosome

Involvement in disease

Spondyloenchondrodysplasia with immune dysregulation (SPENCDI): A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone.

Shakya, M., Raizada, S., Yadav, R., & Singh, P. (2021). Computational Fine-Tuning of Functional Single Nucleotide Polymorphisms Associated with ACP5 Gene to Characterize Missense Mutations Running Title: SNP Analysis of ACP5 Gene.

Hu, Y., Yu, J., Wang, Q., Zhang, L., Chen, X., Cao, Y., ... & Xiong, W. (2020). Tartrate-resistant acid phosphatase 5/ACP5 interacts with p53 to control the expression of SMAD3 in lung adenocarcinoma. Molecular Therapy-Oncolytics, 16, 272-288.

Bai, X., He, C., Fu, B., Kong, X., Bu, J., Zhu, K., ... & Ni, B. (2020). microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity. Cell Cycle, 19(23), 3260-3276.

Hu, Y., Yu, J., Wang, Q., Zhou, Q., Deng, Y., Liu, J., ... & Wang, Y. (2020). Tartrate-resistant acid phosphatase 5 serves as a viable target against pulmonary fibrosis by modulating β-catenin signaling.

Ramesh, J., Parthasarathy, L. K., Janckila, A. J., Begum, F., Murugan, R., Murthy, B. P., ... & Venugopal, B. (2020). Characterisation of ACP5 missense mutations encoding tartrate-resistant acid phosphatase associated with spondyloenchondrodysplasia. PloS one, 15(3), e0230052.

Huang, Y., Wang, L., Mao, Y., & Nan, G. (2019). Long noncoding RNA-H19 contributes to atherosclerosis and induces ischemic stroke via the upregulation of acid phosphatase 5. Frontiers in neurology, 10, 32.

He, C., Bai, X., Li, Y., Sun, H., Kong, X., Fu, B., ... & Xu, S. (2019). Runt-related transcription factor 1 contributes to lung cancer development by binding to tartrate-resistant acid phosphatase 5. Cell Cycle, 18(23), 3404-3419.

Reithmeier, A., Lundbäck, T., Haraldsson, M., Frank, M., Ek‐Rylander, B., Nyholm, P. G., ... & Andersson, G. (2018). Identification of inhibitors of Tartrate‐resistant acid phosphatase (TRAP/ACP 5) activity by small‐molecule screening. Chemical biology & drug design, 92(1), 1255-1271.

Gao, Y. L., Liu, M. R., Yang, S. X., Dong, Y. J., & Tan, X. F. (2018). Prognostic significance of ACP5 expression in patients with lung adenocarcinoma. The clinical respiratory journal, 12(3), 1100-1105.

Ren, X., Shan, W. H., Wei, L. L., Gong, C. C., & Pei, D. S. (2018). ACP5: Its structure, distribution, regulation and novel functions. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 18(8), 1082-1090.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ACP5 protein, His Tag (CAT#: V2LY-0526-LY1904)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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