Mouse Anti-ACPP Recombinant Antibody (V2-179388) (CBMAB-A0690-YC)

Name: Mouse Anti-ACPP Recombinant Antibody (V2-179388)
SKU: CBMAB-A0690-YC
Rating: 5 (1 reviews)

See all ACPP antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179388

Application

ELISA

Immunogen

ACPP (AAH07460, 310 a.a. ~ 418 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Acid Phosphatase, Prostate

Introduction

ACPP is an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript vari

Entrez Gene ID

UniProt ID

P15309

Alternative Names

Acid Phosphatase, Prostate; Prostatic Acid Phosphatase; Thiamine Monophosphatase; Ecto-5-Nucleotidase; EC 3.1.3.2; TMPase; 5-NT;

Function

A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
Isoform 2: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity).
PAPf39: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.

Biological Process

Adenosine metabolic process
Dephosphorylation
Lysosome organization
Neutrophil degranulation
Nucleotide metabolic process
Positive regulation of adenosine receptor signaling pathway
Purine nucleobase metabolic process
Regulation of sensory perception of pain
Thiamine metabolic process

Cellular Location

Isoform 1: Secreted
Isoform 2: Nucleus; Lysosome membrane; Cell membrane; Cytosol.
Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.

PTM

N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection).

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-ACPP Recombinant Antibody (V2-179388)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-ACPP Recombinant Antibody (V2-356437) (CAT#: CBMAB-P0017-YC)

Mouse Anti-ACPP Recombinant Antibody (V2-179389) (CAT#: CBMAB-A0691-YC)

Mouse Anti-ACPP Recombinant Antibody (V2-179391) (CAT#: CBMAB-A0693-YC)

Mouse Anti-ACPP Recombinant Antibody (V2-179390) (CAT#: CBMAB-A0692-YC)

Mouse Anti-ACPP Recombinant Antibody (V2-179393) (CAT#: CBMAB-A0695-YC)

Mouse Anti-ACPP Recombinant Antibody (V2-356435) (CAT#: CBMAB-P0015-YC)

Mouse Anti-ACPP Recombinant Antibody (V2-634089) (CAT#: CBMAB-AP092LY)

Mouse Anti-ACPP Recombinant Antibody (V2-179396) (CAT#: CBMAB-A0698-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry