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Mouse Anti-ACPP Recombinant Antibody (V2-179390) (CBMAB-A0692-YC)

Provided herein is a Mouse monoclonal antibody against Human Acid Phosphatase, Prostate. The antibody can be used for immunoassay techniques, such as ELISA, FC.
See all ACPP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179390
Antibody Isotype
IgG1
Application
ELISA, FC

Basic Information

Immunogen
Raised against PAcP of human origin
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Acid Phosphatase, Prostate
Introduction
ACPP is an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript vari
Entrez Gene ID
55
UniProt ID
P15309
Alternative Names
Acid Phosphatase, Prostate; Prostatic Acid Phosphatase; Thiamine Monophosphatase; Ecto-5-Nucleotidase; EC 3.1.3.2; TMPase; 5-NT;
Function
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
Isoform 2: Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity).
PAPf39: (Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
Biological Process
Adenosine metabolic process
Dephosphorylation
Lysosome organization
Neutrophil degranulation
Nucleotide metabolic process
Positive regulation of adenosine receptor signaling pathway
Purine nucleobase metabolic process
Regulation of sensory perception of pain
Thiamine metabolic process
Cellular Location
Isoform 1: Secreted
Isoform 2: Nucleus; Lysosome membrane; Cell membrane; Cytosol.
Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.
PTM
N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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