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Rabbit Anti-ACSL4 Recombinant Antibody (V2-160818) (CBMAB-F0745-CQ)

This product is a rabbit antibody that recognizes ACSL4. The antibody CBXF-1144 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all ACSL4 antibodies
Published Data
Rabbit Anti-ACSL4 Recombinant Antibody (CBXF-1144) (CBMAB-F0745-CQ) in WB
Down regulation of ACSL4 expression levels in PC-3 cells were analyzed by Western blot. ...View More
Ma, Y., Zhang, X., Alsaidan, O. A., Yang, X., Sulejmani, E., Zha, J., ... & Cai, H. (2021). Long-Chain Acyl-CoA Synthetase 4-Mediated Fatty Acid Metabolism Sustains Androgen Receptor Pathway-Independent Prostate CancerCoordinate Regulation of ACSLs by AR in PCa. Molecular Cancer Research, 19(1), 124-135.

Summary

Host Animal
Rabbit
Specificity
Human
Clone
V2-160818
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Immunogen
Recombinant fragment.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IHC-P1:250
IF(ICC)1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.2, 0.05% BSA, 40% Glycerol
Preservative
0.01% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Acyl-CoA Synthetase Long Chain Family Member 4
Introduction
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants.
Entrez Gene ID
2182
UniProt ID
O60488
Alternative Names
Acyl-CoA Synthetase Long Chain Family Member 4; Fatty-Acid-Coenzyme A Ligase, Long-Chain 4; Long-Chain Fatty-Acid-Coenzyme A Ligase 4; Long-Chain Acyl-CoA Synthetase 4; Lignoceroyl-CoA Synthase; EC 6.2.1.3; LACS 4; FACL4; LACS4;
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET> 14,15-EET> 5,6-EET> 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion.
Biological Process
Dendritic spine development
Embryonic process involved in female pregnancy
Fatty acid metabolic process
Fatty acid transport
Lipid biosynthetic process
Lipid metabolic process
Long-chain fatty acid metabolic process
Long-chain fatty-acyl-CoA biosynthetic process
Long-chain fatty-acyl-CoA metabolic process
Negative regulation of prostaglandin secretion
Neuron differentiation
Positive regulation of cell growth
Positive regulation of insulin secretion
Response to interleukin-15
Response to nutrient
Triglyceride biosynthetic process
Cellular Location
Cell membrane; Microsome membrane; Endoplasmic reticulum membrane; Peroxisome membrane; Mitochondrion outer membrane
Involvement in disease
Mental retardation, X-linked 63 (MRX63): A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
Alport syndrome with mental retardation, midface hypoplasia and elliptocytosis (ATS-MR): An X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, sensorineural hearing loss, mental retardation, midface hypoplasia and elliptocytosis.
Topology
Helical: 8-28 aa
Cytoplasmic: 29-711 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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