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Mouse Anti-ADAM2 Recombinant Antibody (V2-179772) (CBMAB-A1134-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAM Metallopeptidase Domain 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ADAM2 antibodies
Published Data
Fig.1 Effect of cholesterol efflux on the gradual conversion of 46-kDa form of ADAM2 to 27-kDa form.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179772
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ADAM2 (NP_001455, 376-476 aa) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAM metallopeptidase domain 2
Introduction
ADAM2 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involvin
Entrez Gene ID
2515
UniProt ID
Q99965
Alternative Names
ADAM Metallopeptidase Domain 2; Cancer/Testis Antigen 15; Fertilin Subunit Beta; PH30-Beta; FTNB; CT15; PH30; Disintegrin And Metalloproteinase Domain-Containing Protein 2;
Function
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
Biological Process
Binding of sperm to zona pellucida
Cell adhesion
Fusion of sperm to egg plasma membrane involved in single fertilization
Cellular Location
Membrane
Topology
Extracellular: 175-686 aa
Helical: 687-707 aa
Cytoplasmic: 708-735 aa
PTM
The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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