Mouse Anti-ADAM2 Recombinant Antibody (V2-179773) (CBMAB-A1135-YC)

Name: Mouse Anti-ADAM2 Recombinant Antibody (V2-179773)
SKU: CBMAB-A1135-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179773

Application

ELISA, WB

Immunogen

ADAM2 (NP_001455, 376 a.a. ~ 475 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in PBS, pH 7.2

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ADAM metallopeptidase domain 2

Introduction

ADAM2 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involvin

Entrez Gene ID

11495

UniProt ID

Q60718

Alternative Names

ADAM Metallopeptidase Domain 2; Cancer/Testis Antigen 15; Fertilin Subunit Beta; PH30-Beta; FTNB; CT15; PH30; Disintegrin And Metalloproteinase Domain-Containing Protein 2;

Function

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

Biological Process

Binding of sperm to zona pellucida
Cell adhesion
Fusion of sperm to egg plasma membrane involved in single fertilization

Cellular Location

Membrane

Topology

Extracellular: 175-686 aa
Helical: 687-707 aa
Cytoplasmic: 708-735 aa

PTM

The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.

Al-Shabebi, A., Althnaian, T., & Alkhodair, K. (2021). Localization and expression of ADAM2 in the dromedary camel testis, epididymis and sperm during rutting season. Animal Reproduction, 18.

Heidari, M., Darbani, S., Darbandi, M., Lakpour, N., Fathi, Z., Zarnani, A. H., ... & Sadeghi, M. R. (2020). Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection. Human Fertility, 23(2), 123-133.

Zhang, B. J., & Yuan, C. X. (2019). Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats. Biomedicine & Pharmacotherapy, 109, 217-225.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-ADAM2 Recombinant Antibody (V2-179772) (CAT#: CBMAB-A1134-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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