Mouse Anti-ADAM22 Recombinant Antibody (V2-179778) (CBMAB-A1140-YC)

Name: Mouse Anti-ADAM22 Recombinant Antibody (V2-179778)
SKU: CBMAB-A1140-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-179778

Application

IS, WB, IHC

Immunogen

This monoclonal antibody was raised against a fusion protein corresponding to amino acids 757-857 of mouse ADAM22 protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1-10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

1 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ADAM Metallopeptidase Domain 22

Introduction

ADAM22 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involvi

Entrez Gene ID

53616

UniProt ID

Q9P0K1

Alternative Names

ADAM Metallopeptidase Domain 22; Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 2; A Disintegrin And Metalloproteinase Domain 22; Metalloproteinase-Disintegrin ADAM22-3; ADAM 22; MDC2; Disintegrin And Metalloproteinase Domain-Containi

Function

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Biological Process

Adult locomotory behavior
Cell adhesion
Central nervous system development
Myelination in peripheral nervous system
Negative regulation of cell adhesion
Neurotransmitter receptor localization to postsynaptic specialization membrane

Cellular Location

Cell membrane; Axon

Involvement in disease

Developmental and epileptic encephalopathy 61 (DEE61): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE61 is an autosomal recessive condition characterized by onset of seizures in infancy.

Topology

Extracellular: 223-736 aa
Helical: 737-757 aa
Cytoplasmic: 758-906 aa

PTM

The precursor is cleaved by a furin endopeptidase.

Zhao, N., Su, N., Wang, G., Fu, D., Gao, F., & Zhang, Y. (2021). microRNA-184 enhances the sensitivity of pheochromocytoma-12 cells to doxorubicin by targeting ADAM22. Molecular & Cellular Toxicology, 17(2), 123-132.

Lee, S. H., Kwon, N. S., Baek, K. J., Yun, H. Y., & Kim, D. S. (2020). LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-κB pathway in response to LPS in human keratinocytes. Cytokine, 126, 154872.

Charmsaz, S., Doherty, B., Cocchiglia, S., Varešlija, D., Marino, A., Cosgrove, N., ... & Young, L. S. (2020). ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis. BMC medicine, 18(1), 1-14.

Zhang, S. M., Jiang, L., Zhao, X., Liu, J. F., Liang, B., Liu, C., ... & Ma, C. S. (2019). A disintegrin and metalloprotease 22 accelerates neointima formation by activating ERK signaling. Atherosclerosis, 283, 92-99.

Ren, L., Wu, C., Yang, K., Chen, S., Ye, P., Wu, J., ... & Xia, J. (2018). A disintegrin and metalloprotease‐22 attenuates hypertrophic remodeling in mice through inhibition of the protein kinase B signaling pathway. Journal of the American Heart Association, 7(2), e005696.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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