ADAM22

ADAM22 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involvi
Full Name
ADAM Metallopeptidase Domain 22
Function
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
Biological Process
Adult locomotory behavior
Cell adhesion
Central nervous system development
Myelination in peripheral nervous system
Negative regulation of cell adhesion
Neurotransmitter receptor localization to postsynaptic specialization membrane
Cellular Location
Cell membrane; Axon
Involvement in disease
Developmental and epileptic encephalopathy 61 (DEE61): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE61 is an autosomal recessive condition characterized by onset of seizures in infancy.
Topology
Extracellular: 223-736 aa
Helical: 737-757 aa
Cytoplasmic: 758-906 aa
PTM
The precursor is cleaved by a furin endopeptidase.
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Anti-ADAM22 antibodies

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Mouse Anti-ADAM22 Recombinant Antibody (V2-179783) (CBMAB-A1145-YC)

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Target: ADAM22
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179783
Application*: WB, IP
Datasheet SDS

Mouse Anti-ADAM22 Recombinant Antibody (V2-179779) (CBMAB-A1141-YC)

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Target: ADAM22
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179779
Application*: IP, WB
Datasheet SDS

Mouse Anti-ADAM22 Recombinant Antibody (V2-179778) (CBMAB-A1140-YC)

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Target: ADAM22
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-179778
Application*: IS, WB, IH
Datasheet SDS

Mouse Anti-ADAM22 Recombinant Antibody (V2-179777) (CBMAB-A1139-YC)

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Target: ADAM22
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: V2-179777
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ADAM22 Recombinant Antibody (V2-179776) (CBMAB-A1138-YC)

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Target: ADAM22
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: V2-179776
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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