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Rat Anti-ADAM33 Recombinant Antibody (V2-179792) (CBMAB-A1154-YC)

Provided herein is a Rat monoclonal antibody against Mouse ADAM Metallopeptidase Domain 33. The antibody can be used for immunoassay techniques, such as WB, IP.
See all ADAM33 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
V2-179792
Antibody Isotype
IgG2b
Application
WB, IP

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse ADAM33 Ectodomain, Glu205-Ala702.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB2 μg/ml
IP25 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAM Metallopeptidase Domain 33
Introduction
ADAM33 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involvi
Entrez Gene ID
110751
UniProt ID
Q923W9
Alternative Names
ADAM Metallopeptidase Domain 33; A Disintegrin And Metalloproteinase Domain 33; C20orf153; ADAM 33; Disintegrin And Metalloproteinase Domain-Containing Protein 33; Disintegrin And Reprolysin Metalloproteinase Family Protein;
Biological Process
Proteolysis
Cellular Location
Membrane
Involvement in disease
Asthma (ASTHMA): The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Topology
Extracellular: 30-701 aa
Helical: 702-722 aa
Cytoplasmic: 723-813 aa
PTM
The precursor is cleaved by a furin endopeptidase.

Mamoor, S. (2021). Differential expression of ADAM33 in cancers of the breast.

Zihlif, M., Imraish, A., Al-Rawashdeh, B., Qteish, A., Husami, R., Husami, R., ... & Lee, S. J. (2021). The Association of IgE Levels with ADAM33 Genetic Polymorphisms among Asthmatic Patients. Journal of personalized medicine, 11(5), 329.

Yan, F., Hao, Y., Gong, X., Sun, H., Ding, J., & Wang, J. (2021). Silencing a disintegrin and metalloproteinase‑33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling. Molecular Medicine Reports, 24(1), 1-12.

Ghani, M. U., Sabar, M. F., Iqbal Bano, M. S., Akram, M., Ifrah Khalid, A. M., & Khan, M. U. (2019). Evaluation of ADAM33 gene’s single nucleotide polymorphism variants against asthma and the unique pattern of inheritance in Northern and Central Punjab, Pakistan. Saudi medical journal, 40(8), 774.

Li, H. F., Yan, L. P., Wang, K., Li, X. T., Liu, H. X., & Tan, W. (2019). Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis. Respiratory research, 20(1), 1-18.

Ghaemi, M. R., Hemmati, S., Rezaei, A., Sadr, M., Mohebbi, B., Ghaffaripour, H., ... & Mahdaviani, S. A. (2019). Association of ADAM33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran. Acta Medica Iranica, 635-639.

Fang, L., Wu, J., Huang, T., Zhang, P., Xin, X., & Shi, Y. (2018). TGF-β1 stimulates epithelial‑mesenchymal transition mediated by ADAM33. Experimental and therapeutic medicine, 15(1), 985-992.

Yang, P. J., Hou, M. F., Tsai, E. M., Liang, S. S., Chiu, C. C., Ou‑Yang, F., ... & Wang, T. N. (2018). Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine‑disrupting chemicals. Oncology reports, 40(5), 2766-2777.

Sun, F. J., Zou, L. Y., Tong, D. M., Lu, X. Y., Li, J., & Deng, C. B. (2017). Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis. Brazilian Journal of Medical and Biological Research, 50.

Deng, R., Zhao, F., & Zhong, X. (2017). T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians. Inflammation Research, 66(5).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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