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Rat Anti-ADGRE1 Recombinant Antibody (V2-160157) (CBMAB-F0005-CQ)

This product is a rat antibody that recognizes ADGRE1. The antibody BM8 can be used for immunoassay techniques such as: WB, FC, IHC, IHC-P, IHC-Fr.
See all ADGRE1 antibodies
Published Data
Fig.1 Immune cell numbers in the skin of WT and CD4cre FURIN KO mice.
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Fig.2 Representative plots from CD4+ WT and CD4cre KO mice, showing live-gated cell populations positive for CD4+.
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Fig.3 representative immunoblots of Mdm2, p53, p21Cip1/Waf1, and b-actin expression in fibroblasts.
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Fig.4 Representative immunofluorescent staining for 53BP1 or gH2AX foci.
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Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
V2-160157
Antibody Isotype
IgG2a
Application
WB, IHC-F, IHC, IHC-P

Basic Information

Immunogen
Cultured macrophages.The F4/80 antigen is a 125 kD extracellular membrane protein sensitive to 2-Mercaptoethanol.
Host Species
Rat
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-F1:1,000
IHC-P1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.2, 1% BSA
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adhesion G Protein-Coupled Receptor E1
Introduction
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human2015
Mouse13733
UniProt ID
HumanQ14246
MonseQ61549
Alternative Names
Adhesion G Protein-Coupled Receptor E1; Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like Sequence 1; Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1; EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 1; EGF-Like Module Receptor 1; EMR1 Hormone Receptor; TM7LN3; EMR1;
Function
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Biological Process
Adaptive immune response
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Cellular Location
Cell membrane
Topology
Extracellular: 21-599 aa
Helical: 600-627 aa
Cytoplasmic: 628-634 aa
Helical: 635-656 aa
Extracellular: 657-666 aa
Helical: 667-690 aa
Cytoplasmic: 691-709 aa
Helical: 710-731 aa
Extracellular: 732-747 aa
Helical: 748-776 aa
Cytoplasmic: 777-794 aa
Helical: 795-814 aa
Extracellular: 815-829 aa
Helical: 830-852 aa
Cytoplasmic: 853-886 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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