Rat Anti-ADGRE1 Recombinant Antibody (V2-43340) (CBMAB-E0265-FY)

Name: Rat Anti-ADGRE1 Recombinant Antibody (V2-43340)
SKU: CBMAB-E0265-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

V2-43340

Application

IHC-F, IHC

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.2

Preservative

< 0.09% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Adhesion G Protein-Coupled Receptor E1

Introduction

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

13733

UniProt ID

Q61549

Alternative Names

Emr1; Ly71; F4/80; Gpf480; TM7LN3; DD7A5-7; EGF-TM7

Function

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Biological Process

Adaptive immune response
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway

Cellular Location

Cell membrane

Topology

Extracellular: 21-599 aa
Helical: 600-627 aa
Cytoplasmic: 628-634 aa
Helical: 635-656 aa
Extracellular: 657-666 aa
Helical: 667-690 aa
Cytoplasmic: 691-709 aa
Helical: 710-731 aa
Extracellular: 732-747 aa
Helical: 748-776 aa
Cytoplasmic: 777-794 aa
Helical: 795-814 aa
Extracellular: 815-829 aa
Helical: 830-852 aa
Cytoplasmic: 853-886 aa

Waddell, L. A., Lefevre, L., Bush, S. J., Raper, A., Young, R., Lisowski, Z. M., ... & Hume, D. A. (2018). ADGRE1 (EMR1, F4/80) is a rapidly-evolving gene expressed in mammalian monocyte-macrophages. Frontiers in immunology, 9, 2246.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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